Phlebolymphology N°41

Phlebolymphology N°41 (2003)

OBITUARY C. ALLEGRA – Phlebolymphology – 2003 PHLEBOLOGY Mechanisms of onset of chronic venous insufficiency (CVI) M.R. BOISSEAU – Phlebolymphology – 2003; 161 The causes of edema in chronic venous insufficiency M. VAYSSAIRAT – Phlebolymphology – 2003; 168 REVIEW MPFF at a dose of 500 mg at the very heart of chronic venous insufficiency: results from the meta-analysis presented at the UIP Congress, San Diego, 2003 Phlebolymphology – 2003; 172 LYMPHOLOGY Morphological changes in lymphatic vessels from edema to venous leg ulcer O. ELISKA, M. ELISKOVA – Phlebolymphology – 2003; 177 Body image and quality of life in secondary lymphedema…

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The causes of edema in chronic venous

Michel VAYSSAIRAT Tenon Hospital, Paris, France SUMMARY The edema associated with chronic venous insufficiency (CVI) is the most common type of edema (90%). Like all types of edema, it is defined by an increase in interstitial fluid volume. It differs from other types of edema in terms of its association with microangiopathy of an initially functional and then organic nature, a consequence of the venous stasis which injures the endothelium, impairs endothelial function, and induces severe hemorheological abnormalities. The repercussions at the tissue level are linked to the instigation of inflammatory processes involving numerous chemical mediators, resulting in fibrosis, capillary…

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MPFF at a dose of 500 mg at the very heart of chronic venous insufficiency: results from the meta-analysis presented at the UIP Congress, San Diego, 2003

Dr D.T.S. SHEPHARD BSc. MBBS London, UK. Chronic venous insufficiency (CVI) affects approximately 50% of the general population, of whom the vast majority remain untreated.1-3 Equally, venous leg ulcers (the most severe stage of CVI) are found in more than 1% of the adult general population and in 4% to 5% of patients aged 80 and over.4 In addition, the Guidelines of the American Venous Forum state that the recurrence rate for venous leg ulcer is in fact as high as 25% per year.5 In patients noncompliant with therapy, several studies have demonstrated a much faster rate of venous leg…

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Body image and quality of life in secondary lymphedema of the upper limb

Françoise ALLIOT-LAUNOIS Hôpital Pitié Salpétrière Paris, France INTRODUCTION By definition, the goal of all treatment is to improve the patient’s state of health. The quality of life of the patient has an important role to play alongside the objective of cure or remission. The objectives of contemporary medicine consist not only of prolonging life expectancy, but also lessening the consequences of disease and improving quality of life. Next to physiological parameters, studies of quality of life are invaluable complements to medical assessment in order to evaluate the subjective state of health and its progression. The repercussions of quality of life…

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Morphological changes in lymphatic vessels from edema to venous leg ulcer

Oldrich ELISKA M. ELISKOVA Prague, Czech Republic INTRODUCTION Most chronic ulcers of the lower extremity are caused by insufficiency of the deep venous system including the perforating veins. Venous crural ulcer is the last, and a very severe, complication of venous insufficiency. If the deep venous system and the perforating veins are insufficient, then the pressure in the superficial veins is significantly greater. A longer duration of venous hypertension results in increased transudation of plasma to the pericapillary space. As a result, the interstitium is overloaded with fluid, lipids, proteins, and products of cellular degradation. An increased amount of extracellular…

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Mechanisms of onset of chronic venous insufficiency (CVI)

Professor Michel R. BOISSEAU Université de Bordeaux II Bordeaux, France. The pathophysiology of CVI remained relatively obscure until recently, but recent advances relating hemodynamic disorders to cell biology have shed light on how its mechanisms interlink. CVI may be due to hereditary abnormalities of vessel walls or tissues, or appear to be secondary to deep vein thrombosis. However, it is usually apparently primary, with which this analysis is concerned. The cause of CVI is then related to a circle of actions, including the progression of venous hypertension (VH), leading to disturbances of blood flow and venous stasis. These two factors…

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Phlebolymphology N° 41 – Obituary

IN MEMORY OF PROFESSOR J.A. JIMENEZ COSSIO We would all like to die in the arms of people who loved us. Doctors devoted to research and conferences have two families: the wife and children on one hand, and the international scientific stage on the other. The accusation of neglecting family because of work and conferences is quite frequent among doctors and often well-founded. My friend Jimenez Cossio was a rare example of the balance between the man with his affections and the scientist. Fate chose for him a death in the arms of friends and colleagues on his natural stage,…

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