Phlebolymphology N°44

Phlebolymphology N°44 (2004)

EDITORIAL Editorial H. Partsch – Phlebolymphology – 2004 PHLEBOLOGY The role of matrix metalloproteinases (MMPs) and their inhibitors in venous leg ulcer healing Y. HEROUY – Phlebolymphology – 2004; 231 Classification of primary varicose veins of the lower extremities: a consensus statement fron Latin America R. SIMKIN, J. ULLOA – Phlebolymphology – 2004; 244 ABSTRACT Relationship between signs, symptoms, reflux, and quality of life in patients with chronic venous desease M. PERRIN, B. ARNOULD – Phlebolymphology – 2004; 249 REVIEW Symptoms and quality of life: a serious and significant relationship Phlebolymphology – 2004; 250 LYMPHOLOGY Lymphatic function in severe venous…

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Symptoms and quality of life: a serious and significant relationship

I – EARLIEST SYMPTOMS OF CVI: A VERY DISABLING QUALITY OF LIFE Chronic venous insufficiency (CVI) is a serious clinical condition affecting a large number of people, and is important both from an epidemiological point of view, and on account of its socioeconomic repercussions.1 In the Western world, the consequences of the high prevalence of CVI are well known, as are the costs of diagnostic procedures and treatment programs as well as the significant amount of working hours lost and the repercussions on quality of life.2-4 A specific questionnaire for CVI (CIVIQ) has been in use since 1992, with surprising…

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Lymphatic function in severe chronic venous insufficiency

Peter S. MORTIMER, Ian C. PEARSON St George’s Hospital Medical School, London, UKy SUMMARY Clinical and laboratory evidence confirm that in chronic venous insufficiency (CVI) there is microangiopathy of the lymphatic network. The resulting lymphatic dysfunction leads to chronic edema which complicates the clinical picture of severe CVI. Optimum management requires measures to improve lymphatic drainage as well as attending to the venous disease. Exercise, elevation, and compression are principles of treatment effective in both pathologies. ABSTRACT The veins and lymphatics have a similar embryological origin and anatomy. When pathological changes occur in the venous system, there are microangiopathic changes…

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1st Latin American Consensus on the management of lymphedema

José L. CIUCCI and the Consensus Group* Central Military Hospital, Buenos Aires, Argentina SUMMARY From 21 to 23 March 2003, the First Latin American Consensus Conference on the management of lymphedema was held in Buenos Aires, Argentina. The panel was composed of distinguished Latin American experts* in the area of lymphology, who discussed the following topics: definition and classification of lymphedema; diagnostic methods including lymphoscintigraphy, colour Doppler ultrasonography, direct or contrast capillaroscopy, and magnetic resonance imaging. Treatments: manual lymphatic drainage, sequential pneumatic compression, elastic compression, and benzopyrones. Multidisciplinary management: the nervous system and lymphedema, lymphedema and pain, the musculoskeletal system…

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Relationship between signs, symptoms, reflux, and quality of life in patients with chronic venous disease

Michel PERRIN, Benoît ARNOULD* *Perrin M, Arnould B. Relationship between signs, symptoms, reflux, and quality of life in patients with chronic venous disease. Paper presented at the American Venous Forum Congress. Background: Quality of life (QoL) of patients suffering from chronic venous disease (CVD) has been shown to be globally impaired. Little is known about the individual impact of clinical parameters on the QoL of patients with CVD. Objective: To assess the impact of demographic data, clinical data, signs, and symptoms on the QoL of patients with CVD. Methods: Patients: Symptomatic patients, diagnosed as CEAP clinical class 0 to 4,…

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Classification of primary varicose veins of the lower extremities: a consensus statement from Latin America

Roberto SIMKIN, Jorge ULLOA Co-Chairmen Michel Loustric Coordinator FACULTY Hector CALDEVILLA Mario H. GENERO Newton de BARROS, Jr. Almeida R. HAMILTON R. MOURA Raul POBLETE Jorge FERNANDEZ-DIEZ Marcelo PARAMO DIAZ Luis SIGLER J. Leonel VILLAVICENCIO Cuernavaca, Mexico, February 1998 Miami, Florida. January 1999, Supported by an unrestricted educational grant by the Institut de Recherches Internationales Servier INTRODUCTION This document is the result of two consensus conferences organized with the collaboration of a group of specialists representing several Latin American countries, who met with the purpose of establishing a classification of primary varicose veins. The Latin American Consensus Committee (LACC) met…

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The role of matrix metalloproteinases (MMPs) and their inhibitors in venous leg ulcer healing

Yared HEROUY From the Department of Dermatology, University Hospital, Freiburg, Germany SUMMARY Different hypotheses have been postulated to describe the cause of venous leg ulceration including the “fibrin cuff hypothesis” with pressure-damaged capillary vessels and the “white cell trapping hypothesis” based on accumulated leukocytes. To date, several studies have revealed the important role of matrix metalloproteinases (MMPs) in the process of venous leg ulcer formation and contributed significantly to better understanding of the pathogenesis of venous leg ulcers. MMPs, also known as matrixins, hydrolyze components of the extracellular matrix. Currently over 20 MMP genes have been identified in humans, and…

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Phlebolymphology 44 – Editorial

The articles in this issue of Phlebolymphology deal with very interesting areas of phlebolymphology. A special mention is to be given to the Latin American consensus on the management of lymphedema which held its prior conference under the chairmanship of Dr Ciucci. We do welcome this excellent initiative. New proposals for a classification of primary varicose veins of the lower extremities have come from a Latin American consensus group under the leadership of Roberto Simkin and Jorge Ulloa. The authors state that their intention is not to replace the CEAP classification, but to simplify and to refine the clinical segment…

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