Phlebolymphology N°49

Phlebolymphology N°49 (2005)

EDITORIAL Editorial H. Partsch – Phlebolymphology – 2005 PHLEBOLOGY Deep venous reconstructive surgery to treat reflux in the lower extremities M. Perrin – Phlebolymphology – 2005; 375 First Consensus Meeting on Venoactive Agents and Review of their Clinical Benefits C. GARDE – Phlebolymphology – 2005; 384 REVIEW Protection of the microcirculation during ischemia/reperfusion is enhanced by micronization of purified flavonoid fraction F. Z. G. A. CYRINO, D. A. BOTTINO, E. BOUSKELA – Phlebolymphology – 2005; 397 PHLEBOLOGY Apoptosis and cell cycle regulation in the vein wall – new elements related to varicose vein occurrence T. URBANEK – Phlebolymphology – 2005;…

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Protection of the microcirculation during ischemia/reperfusion isenhanced by micronization of purified flavonoid fraction

F. Z. G. A. CYRINO, D. A. BOTTINO, E. BOUSKELA Laboratório de Pesquisas em Microcirculação, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil ABSTRACT This study was designed to evaluate the importance of micronization on the protective effect of micronized purified flavonoid fraction (MPFF) on increases in macromolecular permeability induced by ischemia/reperfusion in the hamster cheek pouch microcirculation. Male hamsters (Mesocricetus auratus) were treated orally, twice a day, with vehicle (lactose), MPFF and nonmicronized purified flavonoid fraction (PFF) at 5, 20, 80, and 320 mg/kg per day for 10 consecutive days. On the 11th day, cheek pouches…

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Apoptosis and cell cycle regulation in the vein wall – new elements related to varicose vein occurrence

Tomasz URBANEK Medical University of Silesia Katowice, Poland SUMMARY According to the majority of pathological studies in varicose vein specimens, various structural changes have been documented, including an irregular accumulation of the extracellular matrix within the vein wall and the disruption of the smooth muscle cell (SMC) bundles. Valve injury seems not to be the only factor leading to varicose vein development, and for vein dilation additional factors related to vein wall homeostasis disturbances are needed. Extracellular matrix accumulation within the vein wall related to SMC phenotype transdifferentiation and secretory activity can result in weakening of the vein wall. Among…

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First Consensus Meeting on Venoactive Agents and Review of their Clinical Benefits

Claude GARDE Organizer of the One-Day Conference, La Baule, France CONSENSUS COMMITTEE N°2 “EFFECTS OF VENOACTIVE AGENTS ON THE SYMPTOMS OF CHRONIC VENOUS DISEASE” Edema associated with chronic venous disease is a commonly mentioned clinical sign. Venoactive agents are the most usual “short cut” because of better compliance than with elastic compression. The aim of this meeting was to define the usefulness of this class of agents in management of edema and the methods for assessing their efficacy in chronic venous disease (CVD). INTRODUCTION Chronic venous disease (CVD) is a common disorder, and its prevalence in the general adult population…

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Deep venous reconstructive surgery to treat reflux in the lower extremities

Michel PERRIN Vascular Surgery Chassieu, France INTRODUCTION The development of deep venous reconstructive surgery (DVRS) for reflux in the lower extremities has been far more limited than arterial reconstructive surgery. This discrepancy may be explained by a variety of factors: – The importance of deep venous reflux (DVR) has been identified as a major pathophysiological factor only in the last 20 years. – Indications for surgery are uncommon. – The efficacy of surgical repair of the deep veins remains controversial. Furthermore, many questions remain partially answered or unanswered. Is there a correlation between clinical and hemodynamic results? When superficial venous…

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Phlebolymphology 49 – Editorial

Chronic venous disease: chronic venous disorder or chronic venous insufficiency? This issue of Phlebolymphology contains some interesting articles, all dealing with chronic venous disturbances, each of them using different terminology. Michel Perrin’s paper reports on the results of reconstructive surgery for the elimination of deep venous refluxes. There is no question, that these procedures are directed towards normalization of insufficient venous pumping function. The author states that “refluxes related to deep venous insufficiency” are corrected. In this functional context the expression of chronic venous insufficiency (CVI) is certainly justified. It is also made clear that the clinical signs of potential…

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