Phlebolymphology N°54

Phlebolymphology N°54 (Vol 14 – N°1 – 2007)

EDITORIAL Editorial H. Partsch – Phlebolymphology – 2007; 14(1): 2 PHLEBOLOGY What have we learned from recent guidelines on the treatment of venous thromboembolism? R. D. Hull, J. Sheldon – Phlebolymphology – 2007; 14 (1): 3 Update on anticoagulants: clinical support for the use of selective factor Xa inhibitors J. A. Caprini – Phlebolymphology – 2007; 14 (1): 17 Pharmacological treatment of chronic venous disorders M. Perrin and G. Geroulakos – Phlebolymphology – 2007; 14 (1): 23 Popliteal vein entrapment: an unrecognized cause of failure in surgery for superficial venous insufficiency R. Milleret – Phlebolymphology – 2007; 14 (1): 31…

Full text

What have we learned from recent guidelines on the treatment of venous thromboembolism?

Russell D. HULL, Jeanne SHELDON Department of Medicine, University of Calgary, Calgary, Canada ABSTRACT Overwhelming evidence indicates that the quality of randomized, controlled trials reporting has been suboptimal. Accordingly, the extended CONSORT statementprovides recommendations that will profoundly impact the design, conduct, and reporting of new drug trials. Additionally, registration of all trials in a public repository ensures that every trial becomes part of the public record, allowing clinicians to explore the full range of clinical evidence. Finally, QUORUM addresses standards for improving the quality of reporting meta-analyses of randomized, controlled, clinical trials. These improvements in the reporting of trials will…

Full text

Update on anticoagulants: clinical support for the use of selective factor Xa inhibitors

Joseph A. CAPRINI Louis W. Biegler Professor of Surgery and Bioengineering Department of Surgery, Evanston Northwestern Healthcare, Evanston, IL, USA Northwestern University Feinberg School of Medicine, Chicago, IL, USA and Robert R. McCormick School of Engineering and Applied Sciences, Evanston, IL, USA ABSTRACT Over the past decade, a number of new anticoagulant compounds have been developed, including the low-molecular-weight heparins (LMWHs) and the factor Xa inhibitors fondaparinux and idraparinux. Factor Xa inhibitors are powerful anticoagulants that act by producing a reversible conformational change in the antithrombin III molecule. Unlike unfractionated heparin and warfarin, these new compounds, which have a linear…

Full text

Popliteal vein entrapment: an unrecognized cause of failure in surgery for superficial venous insufficiency

René MILLERET VEIN CENTER, Montpellier, France SUMMARY Positional compression of the popliteal vein syndrome, or popliteal vein entrapment, often goes unrecognized. For the last 5 years, we have systematically sought to detect this condition in cases where clinical signs suggest its presence. These are: edema related to position, cramps associated with prolonged standing, exertional pain together with cramps and swelling of the calf muscle in athletes, and asymmetry of the circumference of the anterior and posterior tibialis muscles. The most frequent circumstances in which this condition is detected are: • intensive muscle-building training in young women who practice highrisk sports;…

Full text

Pharmacological treatment of chronic venous disorders

Michel PERRIN1 and George GEROULAKOS2 1. Vascular Surgeon, Chassieu, France 2. Consultant Vascular Surgeon, Ealing and Charing Cross Hospital, Senior Lecturer, Department of Vascular Surgery, Imperial College of Science Technology and Medicine, London, UK The term chronic venous disorder (CVD) is used to denote all abnormal clinical changes that result from venous disease of the lower extremities, and that have a chronic course.1 According to this definition, CVD includes patients who present with so-called symptoms and/or signs of venous disease that characterize each class of CVD in the Clinical, Etiological, Anatomical, Pathophysiological (CEAP) classification,2 from class C0s to class C6….

Full text

Book review

VENOUS DISEASE SIMPLIFIED A review by John J. Bergan In today’s medical publishing, this book is unique. This is because it is almost entirely about venous insufficiency and venous reflux. Despite the fact that venous insufficiency is exceedingly common, no recent book deals exclusively with this subject. This book brings under one cover the opinions of 25 physicians, most of whom have published heavily in British and international journals. Collectively, they have contributed clearly formulated chapters on primary varicose veins, management of recurrent varicose veins, quality of life, in addition to essays on symptomatology, history, and epidemiology. Altogether, very good…

Full text

Phlebolymphology N°54 – Editorial

This issue of Phlebolymphology contains some excellent reviews on the management of venous thromboembolic disease. Russell Hull, who is one of the leading clinical scientists in this field, together with his co-worker Jeanne Sheldon, presents proposals on how to conduct and report new drug trials, and gives an overview on the state of the art of how to treat patients with venous thromboembolism, based on recommendations from consensus papers. Colleagues, who are planning randomized controlled trials, will find very important suggestions that will help to improve the quality of their studies. An update on the use of factor Xa inhibitors…

Full text