Phlebolymphology N°61

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Kearon C, Kahn S R, Agnelli G, Goldhaber S, Raskob G E, and Comerota A J. Antithrombotic Therapy for Venous Thromboembolic Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008;133:454S-545S A Review by Grégoire LE GAL The 8th edition of a “bedtime reading“ work for physicians involved in the management of Venous Thromboembolic Disease (VTED) (“Antithrombotic and Thrombolytic Therapy, American College of Chest Physicians Evidence- Based Practice Guidelines”, 8th edition) has just been published. This new volume, which is almost 1000 pages long, presents a state of the art description of antithrombotic agents (platelet anti-aggregants,…

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New computer tools for virtual dissection to study the anatomy of the vascular system

Jean-François UHL1,2 Sylvain ORDUREAU2,3 1 – Centre de Chirurgie des Varices, 113 Avenue Charles De Gaulle, Neuilly/Seine, France 2 – Unité d’anatomie numérique – Biomédicale des Saints-Pères, Université Paris 5 Descartes France 3 – Useful Progress – 45 rue des Saints Pères, Paris, France SUMMARY The aim of this paper is to demonstrate the major role played by the new computerized imaging tools available today in the fields of morphology and vascular anatomy. For anatomical studies or educational purposes, they enhance classic techniques. Three-dimensional reconstruction, which is already used in daily clinical practice, will be the basis for computation of…

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Prevalence of venous leg ulcer: the importance of the data collection method

Olle NELZEN Skaraborg Leg Ulcer Centre & Dept of Vascular Surgery Skaraborg Hospital/KSS Skövde, Sweden ABSTRACT Many epidemiological studies have been performed to assess leg ulcer prevalence, but not all have given reliable results due to weaknesses in the methodology. A proper prevalence assessment is not easily done and requires time and effort. Most studies have just focused on prevalence of leg ulcers of all causes and only a few have really validated the leg ulcer diagnosis objectively by use of hand-held Doppler, color Doppler ultrasound, or plethysmography. There are many pitfalls in performing a prevalence study of venous leg…

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Assessment of treatment efficacy on venous symptoms: the example of MPFF at a dose of 500 mg

Françoise PITSCH Servier International Neuilly-sur-Seine, France INTRODUCTION Leg symptoms are the most frequent reason why patients with chronic venous disease seek medical help. The patient hopes to get rid of them. This may explain the high consumption of venoactive drugs (VADs) in 10 countries (mostly European) in a recent survey: 17 million people per year are treated with VADs,* while 140 million among the adult population in these countries complain of leg symptoms.** The relationship between venous symptoms and venous signs is tenuous, as it is between venous symptoms and venous reflux. Therefore the medical literature concludes that these venous…

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Neovalve reconstruction in postthrombotic syndrome. Technique, indications, and results

Oscar MALETI Marzia LUGLI Department of Cardiac, Thoracic, Vascular Surgery Hesperia Hospital Modena, Italy ABSTRACT Patients with leg venous ulcer (C6 patients according to the CEAP classification) affected by deep venous reflux often fail to respond to conservative therapies, and the presence of non-healing or recurrent ulcers may lead one to consider surgery. However, even if surgery is properly indicated, traditional techniques such as femoral transposition and valve transplantation are not always suitable, and in these cases a de novo valve reconstruction represents a surgical opportunity. Our neovalve reconstruction technique consists in creating an intimal flap by performing a wall…

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Interaction between ageing, inflammation process, and the occurence of varicose veins

Julia Buján Gemma Pascual Juan M. Bellón Department of Medical Specialities Department of Surgery Faculty of Medicine, University of Alcalá Alcalá de Henares Madrid, Spain SUMMARY Failure of the vein wall continues to be a subject of intense research, the aim of which is to establish a cause that will allow us to prevent or at least slow down this undesirable process. We have investigated the role played by inflammatory cells, especially leukocytes, in the etiology of varicose veins. We hypothesize that venous insufficiency could result from the interaction between two processes: tissue aging and abnormalities in the leukocyte/endothelial cell…

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Phlebolymphology N°61 – Editorial

Dear Readers, In their article entitled “Interaction between ageing, inflammation process, and the occurence of varicose veins”, Julia Buján and coworkers from Spain report interesting immunohistochemical findings on leg veins in normal subjects and varicose veins in chronic venous disease patients. Specimens were obtained from aortocoronary bypass and varicose vein surgery and were differentiated according to age: patients under and over 50. This approach showed that inflammatory cells play an important role in both the aging process and the development of varicose veins. Oscar Maleti and Marzia Lugli from Modena, Italy, give an overview of their experiences with the revolutionary…

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Phlebolymphology N°61 (Vol 15 – N°4 – 2008)

EDITORIAL Editorial H. Partsch – Phlebolymphology – 2008 ; 15(4): 122 PHLEBOLOGY Interaction between ageing, inflammation process, and the occurence of varicose veins J. Buján, G. Pascual, J. M. Bellón – Phlebolymphology – 2008; 15 (4): 123-130 Neovalve reconstruction in postthrombotic syndrome. Technique, indications, and results O. Maleti, M. Lugli – Phlebolymphology – 2008; 15 (4): 131-136 Assessment of treatment efficacy on venous symptoms: the example of MPFF at a dose of 500 mg F. Pitsch – Phlebolymphology – 2008; 15 (4): 137-142 Prevalence of venous leg ulcer: the importance of the data collection method O. Nelzen – Phlebolymphology –…

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