Phlebolymphology N°67

Review by Michel Perrin

Cao P, Giannoukas AD, Moll FL, Veller M. Vascular Aneurysms. Publisher Argonafton & Filellinon. 38221 Volos-Greece. University of Thessaly Press 2009. ISBN 978-960-8029–85-89 The LARISSA INTERNATIONAL VASCULAR ENDOVASCULAR SYMPOSIUM (LIVES) held every year in June in Greece and organized by Professor Athanasios D. Giannoukas has become a “must”. This year the meeting was devoted to vascular aneurysms, and the book published in 2009 by the organizer in collaboration with Frans L. Moll, Piergiorgio Ciao, and Martin Veller deserves both mention and analysis. The 400-page hardback book in glazed paper contains contributions by 84 authors and is divided into 6 richly…

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Venous Clinical Severity Score and quality-of-life assessment tools: application to vein practice

Michael A. VASQUEZ and Carolyn E. MUNSCHAUER SUNY Buffalo Surgery, The Venous Institute of Buffalo, New York, USA However beautiful the strategy, you should occasionally look at the results. Sir Winston Churchill Outcome assessment is a term that dominates the global landscape of vascular interventions and has become a catchphrase for determination of the acceptable standard. Its tools allow us to stratify disease and therapy. In his 1996 presidential address to the Society of Vascular Surgery, Rutherford stated: “The results of therapy for vascular diseases have little meaning if presented in isolation, no matter how uniform and valid the criteria…

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Understanding the mechanisms of lymphangiogenesis: a hope for cancer therapy?

Jonathan P. SLEEMAN1,2 1. University of Heidelberg, Medical Faculty Mannheim, Ludolf-Krehl-Str. 13-17, D-68167 Mannheim, Germany. 2. Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, D-76021 Karlsruhe, Germany. ABSTRACT The last fifteen years have witnessed a rapid deepening of our understanding of both the molecular biology of lymphatic vessels and the formation of new lymphatic vessels during lymphangiogenesis. Following the discovery that VEGFR-3, a transmembrane receptor tyrosine kinase, localizes to lymphatic vessels and can orchestrate lymphangiogenesis, the list of molecular regulators of lymphangiogenesis has continued to grow, and includes growth factors, cell surface proteins, and transcription factors. In addition, molecules…

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Results from detection surveys on chronic venous disease in Eastern Europe

Françoise PITSCH ervier Interntational Suresnes, France INTRODUCTION Chronic venous disease (CVD) is common among general populations.1 Both general practitioners and specialist doctors have to deal with this pathology, which is often mild in presentation but potentially progressive. Despite this, it is acknowledged that CVD is usually overlooked both by doctors who underdiagnose the condition and by patients themselves who rarely consult spontaneously for venous leg problems except in the advanced stages.2 As a consequence, CVD is undertreated, particularly in the early stages. CVD may be associated with a wide range of lower limb symptoms, which may be present from the…

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Local treatment of venous leg ulcers

Patricia SENET Hôpital Tenon Paris, France ABSTRACT The current standard of care for chronic venous ulcers involves the use of compression bandages. Dressings are applied beneath the compression and are used to control the exudates and to maintain the wound in a moist environment. Modern dressings are occlusive or semi-occlusive, classified according to their physical composition. Published systematic reviews of the value of different types of dressings in the management of chronic wounds provide only weak levels of evidence of their clinical efficacy, in terms of healing rate. Nevertheless, the indications for modern dressings were recently determined according to a…

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Venous thromboembolic disease and pregnancy: prevention and treatment

Christine BIRON-ANDREANI Laboratoire d’Hématologie Montpellier, France ABSTRACT The management of venous thromboembolism (VTE) during pregnancy is challenging for several reasons. In this article, we address the following questions: in pregnant women, how do we (i) treat VTE once a diagnosis is confirmed? (ii) assess the risk of VTE, and (iii) manage women with a high risk of VTE? When anticoagulants are required in pregnancy and the puerperium, low-molecular-weight heparin (LMWH) is now the preferred drug, but optimal dosage and monitoring remain unresolved issues. In addition, there is a paucity of reliable information about the risk of VTE in women with…

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Phlebolymphology N° 67 – Editorial

Dear Readers, An interesting mixture of practically important and basic science articles can be found in this issue of Phlebolymphology. The management of venous thromboembolism during and after pregnancy is still widely based on experience because randomized controlled trials in this field are lacking for obvious reasons. Christine Biron-Andreani of the Hematology Unit of the University Hospital in Montpellier gives us a survey of practically very useful, updated recommendations, concerning both prevention and treatment of venous thromboembolic disease, in accordance with the recent ACCP guidelines and supported by numerous references. The choice of a proper wound dressing in venous leg…

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Phlebolymphology N°67 (Vol 17 – N°2 – 2010)

EDITORIAL Editorial Hugo Partsch – Phlebolymphology – 2010 ; 17 (2): 76 PHLEBOLOGY Venous thromboembolic disease and pregnancy: prevention and treatment Christine Biron-Andreani – Phlebolymphology – 2010 ; 17 (2): 77 Local treatment of venous leg ulcers Patricia Senet – Phlebolymphology – 2010 ; 17 (2): 87 Results from detection surveys on chronic venous disease in Eastern Europe Françoise Pitsch – Phlebolymphology – 2010 ; 17 (2): 95 Understanding the mechanisms of lymphangiogenesis: a hope for cancer therapy? Jonathan P. Sleeman – Phlebolymphology – 2010 ; 17 (2): 99 Venous Clinical Severity Score and quality-of-life assessment tools: application to vein…

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