Phlebolymphology N°75

Phebolymphology N°75 – Editorial

Dear Readers, Many roads lead to Rome and many routes may be chosen to treat varicose veins… In this issue of Phlebolymphology, guidelines on the treatment of varicose veins elaborated by a group of prominent American vascular surgeons are reported and commented on by prominent European vascular surgeons (Marzia Lugli and Oscar Maleti from Modena, and Michel Perrin from Lyon). Those who are looking for clear recommendations on which method is the most successful to treat varicose veins in a specific clinical setting will be disappointed. However, the comments of our European colleagues on the American suggestions are quite stimulating….

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VEIN CONSULT Program: interim results from the first 70 000 screened patients in 13 countries

Françoise PITSCH Servier International, Suresnes, France ABSTRACT The VEIN CONSULT Program, a joint initiative between the Union Internationale de Phlébologie and Servier, is the largest global effort to raise awareness of chronic venous disease (CVD) among patients, health care professionals, and health authorities. The aim is to update information on the prevalence of primary CVD in different geographic areas, to compare the management of the disease between countries, and to improve our understanding of the relationship between general practitioners and venous specialists, in order to propose a straightforward approach to earlier diagnosis. The survey was conducted in primary care centers…

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Chronic cerebrospinal venous insufficiency: state of the art and research challenges

Marian SIMKA EUROMEDIC Specialist Clinics, Department of Vascular & Endovascular Surgery, Katowice; Poland ABSTRACT This review discusses a potential vascular basis for multiple sclerosis (MS). The idea that MS could be related to vascular disease is not new, with the first reports describing connections between veins and MS plaques dating from the 19th century. The venous abnormalities found in MS patients, the socalled chronic cerebrospinal venous insufficiency, are currently interpreted as congenital venous malformations. Catheter venography is regarded as the gold standard to assess these lesions, while other tests, such as Doppler sonography and magnetic resonance venography, are much less…

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Review and Comment of the 2011 Clinical Practice Guidelines of the Society for Vascular Surgery and the American Venous Forum

Gloviczki P, Comerota AJ, Dalsing MC, et al. The care of patients with varicose veins and associated chronic venous diseases: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. J Vasc Surg. 2011;53:2S-48S. Marzia LUGLI Modena, Italy Oscar MALETI Modena, Italy Michel PERRIN Lyon, France ABSTRACT The Clinical Practice Guidelines of The Society for Vascular Surgery and The American Venous Forum, published in the 2011 Journal of Vascular Surgery supplement, is the most complete document on the management of varicose veins ever published in English. It is the work of leading members of the American…

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The natural progression of chronic venous disorders: An overview of available information from longitudinal studies

Amanda C. SHEPHERD, Tristan R. LANE, Alun H. DAVIES Academic Section of Vascular Surgery Imperial College School of Medicine Charing Cross Hospital, Fulham Palace Road, London, W6 8RF ABSTRACT Chronic venous disorders remain a common problem worldwide; however, despite increasing research into novel endovenous therapies for the treatment of superficial venous disease, the natural history of primary venous disorders remains poorly understood. The following article provides a review of the longitudinal studies evaluating the progression of chronic venous disorders in the published literature. This includes a summary of the rate of development of venous disease in asymptomatic limbs and the…

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Proteolytic degradation and receptor cleavage in the microcirculation

Geert W. SCHMID-SCHÖNBEIN Department of Bioengineering Institute of Engineering in Medicine University of California San Diego La Jolla California, 92093-0412 ABSTRACT We propose here a previously unrecognized pathogenic mechanism for hypertension and diabetes and the cluster of multifaceted cell dysfunctions characteristic of the metabolic syndrome. The evidence for this new hypothesis is derived from a genetic model with unchecked proteolytic activity, including that of matrix metalloproteinases, which causes cleavage of the extracellular domain of surface receptors and loss of their respective functions. For example, cleavage of the extracellular domain of the β2-adrenergic receptor promotes arteriolar vasoconstriction and elevates central blood…

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Phlebolymphology N°75 (Vol 19 – N°3 – 2012)

EDITORIAL Editorial Hugo Partsch – Phlebolymphology – 2012 ; 19 (3): 106 PHLEBOLOGY Review and Comment of the 2011 Clinical Practice Guidelines of the Society for Vascular Surgery andthe American Venous Forum Marzia LUGLI, Oscar MALETI, Michel PERRIN – Phlebolymphology – 2012 ; 19 (3): 107 Chronic cerebrospinal venous insufficiency: State of the art and research challenges Marian SIMKA (Katowice, Poland) – Phlebolymphology – 2012 ; 19 (3): 121 VEIN CONSULT Program: interim results from the first 70 000 screened patients in 13 countries Françoise PITSCH – Phlebolymphology – 2012 ; 19 (3): 132 The natural progression of chronic venous…

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