Phlebolymphology N°82

Phlebolymphology N°82 – Editorial

Dear Readers, This issue of Phlebolymphology once again brings topics of immediate interest to the fore. A high number of chronic venous ulcers will have a prolonged healing, despite the best medical practices. This could be due to their malignant transformation into squamous cell carcinomas that are referred as “Marjolin’s ulcers.” P. Senet analyzes the connection between cancer and chronic venous ulcers in this issue. She points out that one of the key clues for Marjolin’s ulcer diagnosis is the prolonged duration of the preexisting wound. The review of the foam sclerotherapy trials for the treatment of varicose veins as…

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Cutaneous cancers and chronic leg ulcers

Patricia SENET Hôpital Tenon (Paris 20ème), Service de Dermatologie, UF de Médecine Vasculaire, France   ABSTRACT The association between malignancies and chronic venous ulcer is not rare and include 2 distinct entities: malignant transformations of long lasting venous ulcers and primary ulcerating skin carcinomas misdiagnosed as venous ulcers. Malignant transformation of chronic venous ulcers into squamous cell carcinomas (SCCs), referred to as Marjolin’s ulcer, is characterized by a median duration of 25 years. Malignant transformation of leg ulcers into basal cell carcinomas (BCCs) is still under debate. Skin cancers may also arise de novo, become ulcerated, and mimic chronic venous…

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Randomized control trials on sclerotherapy for varicose veins

Michel Perrin Vascular Surgery, Unite de Pathologie Vasculaire Jean Kulin, Lyon, France   ABSTRACT Ultrasound-guided foam sclerotherapy (UGFS) is presently challenging other operative varices treatment. Randomized controlled trials are considered to be solid, evidence-based studies. In varices management, many randomized trials have been published in order to try to determine what the best treatment option is, and they are discussed in this review. Other randomized controlled trials dealing with varices sclerotherapy are analyzed including: (i) sclerosing agent versus placebo; (ii) liquid versus foam; (iii) the type, dose, and concentration of sclerosing agent; (iv) sclerotherapy in patients with or without thrombophilia;…

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Benefits of micronized purified flavonoid fraction in the reduction of symptoms after operation for hemorrhoidal disease

Vladimir Astas hov, Dmitry Timchenko N.N. Burdenko Main Military Clinical Hospital of the Ministry of Defense of the RF, Moscow, Russia   ABSTRACT Analysis of the treatment of patients with chronic hemorrhoids was carried out in the department of abdominal surgery at the N.N. Burdenko Main Military Clinical Hospital. The use of micronized purified flavonoid fraction (contained in Detralex) in 56 patients with stage II to IV hemorrhoidal disease in the pre- and postoperative period resulted in improved treatment outcomes. The term “hemorrhoids” comes from the Greek words “haema” (blood) and “rhoos” (flowing). This term was first used by Hippocrates…

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Chronic venous disease and the genetic influence

Michel-René Boisseau University Victor Segalen Bordeaux2, Department of Pharmacology, Bordeaux, France   ABSTRACT The etiology and pathophysiology of chronic venous disease (CVD) have been intensively studied in the past decades. The elucidation of mechanisms leading to CVD is a challenging task because acquired phenomena alone are presumably insufficient to explain the full clinical course of the disease. CVD genetic screening adopted the most appropriate methodology to find out which chromosomal and/or gene defects could be responsible for the predisposition. They include family studies, gene expression methods (eg, single candidate gene expression, DNA microarrays), or genotyping methods (eg, single nucleotide polymorphisms,…

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Critical Role of the Vasa Venarum in the Pathogenesis of Chronic Venous Disease.Part II: Therapeutic Implications

Part I was published in Phlebolymphology, vol 20; No4 – 2013 Stephan NEES1, Dominik R. WEISS2, Gerd JUCHEM3, Hugo PARTSCH4 1 Department of Physiology, University of Munich (LMU), 80336 Munich, Germany 2 Department of Transfusion Medicine and Hemostaseology, University of Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany 3 Department of Cardiac Surgery, University of Munich (LMU), 81377 Munich, Germany 4 Emeritus Professor of Dermatology, Medical University of Vienna, Austria   ABSTRACT Standing or sitting for a long duration is accompanied by venous distension and pooling of blood in the larger leg veins and the lower vena cava. Under these conditions, reflux from…

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Phlebolymphology N°82 (Vol 21 – N°2 – 2014)

EDITORIAL Editorial Pier-Luigi ANTIGNANI – (Rome, Italy) – Phlebolymphology – 2014 ; 21 (2): 74 PHLEBOLOGY Cutaneous cancers and chronic leg ulcers Patricia Senet – (Paris, France) – Phlebolymphology – 2014 ; 21 (2): 75 Randomized control trials on sclerotherapy for varicose veins Michel Perrin – (Chassieu, France) – Phlebolymphology – 2014 ; 21 (2): 81 Benefits of micronized purified flavonoid fraction in the reduction of symptoms after operation for hemorrhoidal disease Vladimir Astashov, Dmitry Timchenko – (Moscow, Russian Federation) – Phlebolymphology – 2014 ; 21 (2): 95 Chronic venous disease and the genetic influence Michel-René Boisseau – (Bordeaux, France)…

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